Job Title
Medical Director/Senior Medical Director
Research Associate II
Associate Director/ Director
Assay Design & Implementation Group
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Medical Director/Senior Medical Director
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Medical Director/Senior Medical Director
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Job Description: Seeking an industry-experienced MD to join as Medical Director/Senior Medical Director. The individual should have 5+ years of pharmaceutical/biotech industry clinical trial experience (pre-IND through end of Phase2). Optimal would be someone with either a cardiology or skeletal myopathy(-ies) background.
The Medical Director/Senior Medical Director develops the strategies, designs, implements, monitors and evaluates clinical trials and other associated clinical development programs for small molecule therapeutics. The position will have responsibilities from pre-IND through the end of Phase II clinical trials and will include protocol development, evaluation of efficacy and safety information from ongoing studies, data analysis and interpretation, report writing, and preparation of key regulatory documents. The Medical Director/Senior Medical Director will work closely with internal and external cross-functional stakeholders, external investigators, corporate partners and regulatory authorities and will represent ARMGO in meetings. The position will develop and deliver key presentations, both internally and externally and will lead and participate in FDA or other health authority interactions.
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Education: M.D. (Optimal would be someone with either a cardiology or skeletal myopathy background.)
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Associate Director/ Director Assay Design & Implementation Group
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Associate Director/ Director Assay Design & Implementation Group
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Job Description: The Associate Director/Director is responsible for the design, implementation, troubleshooting and analysis of data from biochemical, membrane- and cell-based assays for small molecule RyR modulators. The Associate Director/Director enables and supports drug discovery efforts and will have responsibilities that include assay development & implementation, data analysis and interpretation, and preparation of reports. The Associate Director/Director will work closely with internal and external cross-functional stakeholders, external investigators, and corporate partners. The Associate Director/Director will represent ARMGO in meetings and will develop and deliver key presentations, both internally and externally.
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Knowledge
| • | Demonstrated track record in the design and implementation of pharmaceutical assay design and small molecule screening. |
| • | Demonstrated hands-on, bench-level leadership and clear scientific decision-making. |
| • | Demonstrated practical experience and success in technical problem-solving and troubleshooting. |
| • | Strong experience in the adaptation of low-throughput filter-based assays to multi-well, medium-throughput formats with a variety of readout technologies. Expertise in assay/automation quality control would be a plus. |
| • | Significant practical experience with membrane-based, cell-based and radioactive ligand filter binding assays. |
| • | Practical experience in data acquisition/analysis and automation of cell-based fluorescent assays, fluorescence microscopy and image analysis would be a plus. |
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Education: Ph.D. (Optimal would be someone with either a cardiovascular or musculoskeletal background.)
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Experience: 7+ years experience in industry (Pharma/Biotech) with significant practical experience in assay design and small molecule screening implementation. Excellent contacts and network in the assay design and screening community. Prior leadership experience in lead discovery and/or assay design & implementation in a pharmaceutical or biotech laboratory environment.
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Languages: English is required. French would be a plus.
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Research Associate II
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Research Associate II
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Job Description: The successful candidate will support discovery and innovation efforts by participation in protein biochemistry assays in research and development.
REQUIRED SKILLS:
| • | Strong core competency in protein and membrane biochemistry |
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| - | Recombinant bacterial expression and protein purification |
| - | Metabolic labeling using E coli expression systems |
| - | Membrane vesicle preparations of striated muscle |
| • | Biochemical/biophysical characterization of skeletal muscle |
| - | Binding assays: Membrane receptor-radioligand binding, immunoprecipitation, filter binding assays, ability to troubleshoot assays |
| - | Immunoblotting, QA/QC of skeletal muscle preparations |
| • | Skeletal muscle functional in vitro assays |
| - | Muscle force analysis of rodent EDL and soleus muscles using Aurora force analyzer |
DESIRED SKILLS:
• Design, construction and propagation of plasmid expression constructs
• Practical experience with qRT-PCR
• Effective oral and written communication, self-management, organization and task planning.
• Demonstrated skills in experimental planning, data analysis and presentation of results
Education: Bachelors or Masters Degree in muscle protein biochemistry in addition to a minimum of 5 years industry experience .
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